Depakote

Yicheng Wong is a 53-year-old widowed Asian male who comes to see you in your office after he was hospitalized for 14 days for a manic episode. Yicheng has bipolar I disorder. He is currently prescribed 1500 mg of divalproex sodium (Depakote ER). He is 5’ 11” and 210 lbs. His most recent VPA level was 45 µg/ml.

What laboratory testing should be ordered prior to starting Depakote?
What is the normal reference range for monitoring Depakote level?
Based on his depakote level and how he presents to you, what changes (if any) would you make with Yicheng’s Depakote ER? Why or why not? Provide the dose, route, and timing/frequency for all medication changes
When would you check another Depakote level (that is, how many days after starting or changing the dose, what time of day/how long after the last dose would you check it)?

Sample Solution

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Mr. Gupta set up a meeting with the stakeholders and CEO of the company to discuss the problem faced by the marketing and sales team of lack of proper tools and methods to manage and conduct the digital marketing campaigns. For this, they require financial support from

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