How has genetic disease affected natural selection in humans?

 

This is for my ecology and evolution class. I would like to theorize in how genetic diseases in humans has affected Charles Darwin’s “Natural Selection” theory.
My research question is currently “How has genetic disease affected natural selection in humans?” But can be alte

Sample Solution

Natural selection is the process through which populations of living organisms adapt and change. Individuals in a population are naturally variable, meaning that they are all different in some ways. Diseases are thought to persist in human populations primarily because of a balance between mutation, genetic drift, and natural selection, with alleles that contribute to disease introduced by mutation, governed in part by random genetic drift, but eventually eliminated from the population of purifying selection (Pritchard JK, Cox NJ. 2002). Host genetics strongly influences an individual`s susceptibility to infectious disease. Pathogens that diminish reproductive potential, either through death or poor health, drive selection on genetic variants that affect resistance.

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