Job advertisement

 

Create a professional job advertisement for a software engineer position to be read by an
applicant either online or in a newspaper or journal.
Please include the following information (in a succinct manner):
-Information regarding the company
-Job Duties and Responsibilities
-Potential Compensation and Benefits
-How the Applicant should apply for the position
-can make up a company
Its best that you review current openings for positions both online and in print

Sample Solution

2- Drug releases when the polymers swell at specific pH conditions:
Another reason for drug release from nanoparticles was the swelling of the materials [96].
At low pH, the polymers, particularly cross-linked polymers, have a compact structure, which considerably decreased the porosity of the matrix. This caused a slower release of drug as a result of the greater resistance for diffusion of the drug out of the nanogel. However, at higher pH, the nanogel particles were in a swollen state with a higher porosity that favored the release of the drug because of the reduction in diffusion resistance.
3- The drug releases as a result of both polymer dissolution and swelling:
There was obscure boundary between drug dissolution and swelling for the carriers. Some nanoparticle systems might release drug through both the mechanisms. Li et al., 2006 [97] studied the release of insulin from chitosan–Eudragit L100-55 nanoparticles in vitro. The results proposed that at low pH, the nanoparticles were covered by Eudragit L100-55, little water permeated into the particles and when the pH value was elevated to 5.8, Eudragit L100-55 dissolved and water penetrated to the core of the particles. The particle size become larger as chitosan swelling and the higher porosity of chitosan caused rapid insulin release.

Depending on their characters, pH sensitive nanoparticles can be mainly divided into two types. One induces drug release at higher pH because of ionizable functional groups on the polymer backbone or side chain, for example, nanoparticles prepared using poly (methacrylic acid) [98], hydroxypropyl methylcellulose phthalate[99] and poly (acrylic acid) grafted poly(vinylidenefluoride)[100]. This kind of nanoparticles is typically used for oral drug delivery [97,101-109], where a physiological pH shifts along GIT facilitates the swelling or dissolution of the carriers. The other kinds of pH-sensitive nanoparticles have a reversed swelling or dissolution behavior of the former. It undergoes swelling in acidic environment and can be used to target tumors, lysosomes and endosomes, where pH is comparatively lo

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