Nonprofit is “ The Women’s Advocacy Center” (in Memphis)

The basic aim of the personalized medicine is applying right therapy to the right population of people by defining disease at the moecular level. So, identifying differences among the individuals support the new treatment methods and pharmaceutical companies to develop new cancer drugs. Patients who have similar clinical outcome and histological tumor type can give different response to the same drug(17). Prediction of who will be a nonresponders reduces the harmfull effect of drug on nonresponders like a potential toxic effect of drug and cost effect. Also when drug companies develop new drug, they focus on the patient population that benefit from drug to increase positive responds(17). U.S. Food and Drug Administration bringed development about targeted therapy. For example, to treat chronic myeloid leukemia and gastrointestinal stromal tumor(18) ,imatinib mesylate is used and to treat breast cancer(19), trastuzumab (Herceptin) is used. Molecular characteristics of these cancer types that are abnormal protein tyrosine kinase activity in chronic myeloid leukemia and gastrointestinal stromal tumor and HER-2 receptor in breastcancer is used as a predictive biomarker. By using these markers only individuals which have these molecular alteration is selected and it means they are favorable for the treatment. Using this way some cancer types’ survival rate is shifted from 0 to 70%(17). This application is used in non-small cell lung cancer treatment with using of mutations screeing. In this cancer type mutation occurs in kinase domain of EGFR. Gefitinib (Iressa) and erlotinib are tyrosine kinase inhibitors drug are used to treat and patients give a higher response to the treatment(20). Also if patient that is never smoked Asian females have adenocarcinomas, these drugs efficient on them(21). On the other hand, if the mutatuions occur at downstream effector KRAS, patient is resistant to to erlotinib(22). Also mutations that is at KRAS have a resistance to cetuximab (Erbitux) and panitumumab (Vectibix) drugs in colon cancer patients. If the KRAS is wild type, these these drugs is effective on the patients(23). These responses that are specific and different are based on molecular profile. Some molecular test are done before the using of cetuximab or panitu

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The Women’s Advocacy Center (WAC) is a nonprofit organization based in Memphis, Tennessee. The WAC seeks to address the social justice issue of gender-based violence by providing resources and support services to victims of domestic and sexual abuse. With such a large undertaking, it is important for the WAC to have an effective plan in place that will enable them to reach their goals. To do this, they need to develop an advocacy team or other approach that can help secure funding and mobilize community action as well as educate and inform individuals about the cause. This team should be made up of passionate individuals who are knowledgeable about gender-based violence, its causes and consequences, as well as strategies for prevention. It is also essential for members of the team to possess good communication skills so they can effectively reach out both locally and nationally seeking support from legislators, funders, faith organizations among others (National Resource Center on Domestic Violence., 2002). The advocacy team should also be equipped with all the necessary tools needed including a formalized budget plan which clearly outlines how funds raised will be allocated; documents detailing key messages they want people to understand; materials like brochures or pamphlets highlighting statistics or current campaigns related their cause; contacts lists of local media outlets etc...(Kuzilwa & Brubaker., 2015). The goal would be for them use all these items when engaging with potential allies so when the time comes various stakeholders know exactly what type of assistance is required. Furthermore, having representatives available at rallies or public events organized by other similar groups may also prove beneficial since it would allow members connect directly with constituents building relationships that could potentially lead more people advocating on behalf issue (Kuzilwa & Brubaker., 2015). Lastly involvement in coalitions formed around topics relevant to their mission statement should also be considered since it could empower the organization while enabling it to further advance its goals (Hutchinsonetal., 2012). In conclusion, developing a successful advocacy program requires dedication but if done properly pays off considerably allowing nonprofits like The Women’s Advocacy Center achieve greater success in fighting against social injustice.