Organization on the concept of “repeatable work
Instructions: Read Case study and answer questions below. Be sure to read the highlighted content prior to answering questions.
Case Study 7.1: The Case of the Variable Laminates
A plywood manufacturer has asked for your assistance in solving a problem in the log-peeling operation. The peeling process consists of soaking de-barked logs in a hot bath, fixing the logs in chucks, and rapidly spinning them while shaving off a continuous thin section called a lamination with a sharp knife blade. The laminations are then cut into sheets to be laid up, glued, and pressed into plywood sheets. The manufacturer is having difficulty maintaining a controlled thickness when peeling laminations from a log.
Discussions with engineering and the process operators indicate that four variables are related to laminate thickness: soak time, soak temperature, knife pressure, and knife setting. The knife setting is pretty straight forward and is not felt to be a source of variation in the process. Specifications call for logs to be soaked for 60 minutes, but no process control for this process is in place. Some logs are peeled after as little as 30 minutes soak time. The operators believe that this causes some of the variation, but they are under the gun to keep the peeler busy, even if it means compromising on the soak time. The engineers feel that knife pressure may contribute to the thickness variation. Knife pressure setting is not standardized—operators set it between 250 psi and 300 psi based on their experience. Soak temperature varies between 150 degrees and 200 degrees, depending upon how much bark has accumulated around the heating coils.
Thickness measurements are made every 15 minutes on the laminate. The variation does not seem to follow a particular pattern.
Design an experiment that will assist the process engineers in determining what actions to take to reduce laminate thickness variation. Provide them with your assessment of the causes of the variation and how to use the results of the experiment to define the optimal operating conditions for the process.
Within this module you will need to complete a response to Case Study 7.1: The Case of the Variable Laminates in your textbook. Please provide the proper headers when answering each question. In your case analysis, be certain to answer the following questions:
1. Design an experiment that will assist the process engineers use in determining what actions to take to reduce laminate thickness variation. Include an assessment of the variables that may be the cause of sub-optimized output.
2. How would you evaluate the organization on the concept of “repeatable work? What recommendations would you have to standardize the manufacturing process? Why is repeatable work so important in continuous improvement activities?
europathy includes a reduction in axon type, axonal vehicle weakness, and a decreased limit of nerve recovery, which are reliant upon axonal cytoskeleton respectability for legitimate nerve work (4). Diminished amalgamation of tubulin mRNA and a raised non-enzymatic glycation of fringe nerve tubulin was depicted. Especially, it was exhibited that following two months of diabetes T alpha 1 alpha-tubulin mRNA is decreased in streptozotocin (STZ)- prompted diabetic rodents (7), and an expansion in tubulin glycation was recognized in the sciatic nerve of STZ-actuated diabetic rodents following fourteen days of diabetes length, which might add to axonal vehicle irregularities by weakness of microtubule work (8, 9). Cerebrum tubulin is likewise glycated in early exploratory diabetes, subsequently influencing its capacity to frame microtubules (10). By and by, this finding was not reproduced in resulting studies, where it was shown that glycation was not related with hindrance of microtubule get together (8, 11). In the sural nerves of diabetic patients it was recognized an expansion in cutting edge glycation final results collection in cytoskeletal proteins (12), recommending that axonal cytoskeletal proteins glycation might assume a part in axonal degeneration polyneuropathy in diabetes.
Tau is a microtubule related protein significant for the security of axonal microtubules. Tau hyperphosphorylation debilitates its limiting to microtubules, changing the dealing course for particles which may eventually prompt synaptic degeneration (13, 14). Diabetes actuates tau hyperphosphorylation in the mind, concerning model in the hippocampus (15), and proteolytic tau cleavage (16), being the two cycles occuring in Alzheimer's sickness (17). Hyperglycemia and insulin brokenness might prompt tau changes, and subsequently may assume a part for the expanded occurrence of Alzheimer's sickness in diabetic patients (16). Tau alteration impedes axonal vehicle through microtubule course of action disturbance and by obstructing axonal dealing course, which can finish in synaptic capacity changes and ensuing neurodegeneration (18, 19). In Alzheimer's illness, glycation of tau might balance out matched helical fibers conglomeration prompting tangle arrangement (20). Almost certainly, comparable cycles might be occuring under diabetes.