Sample Solution

dvantages of polymeric nanoparticles include: [81, 82]
(1) improve the stability of any volatile pharmaceutical agents, simply and economically fabricated in large quantities by a huge number of methods, (2) they present a significant improvement over conventional oral and intravenous routes of administration in terms of efficiency and effectiveness, (3) delivers a higher concentration of pharmaceutical agent to the required location, (4) the selection of polymer and the capability of modifying drug release from polymeric nanoparticles have made them typical choice for cancer therapy, delivery of vaccines, contraceptives and delivery of targeted antibiotics and (5) Polymeric nanoparticles can be easily included into other activities related to drug delivery, such as tissue engineering.

In nanoparticles formulations wide variety of polymers can be used according to the nature of drug and usage. (i.e.) Biodegradable polymers for short term therapy (e.g. Chemotherapeutic agents) and non-biodegradable polymers for long term therapy (e.g. Vaccines) [83].
The PNPs are obtained from synthetic polymers, such as poly- Ɛ-caprolactone [84], poly-acrylamide [85] and polyacrylate [86], or natural polymers, e.g., Albumin [87], DNA[88], chitosan [88, 89] and gelatin [90].Based on in vivo behavior, PNPs may be classified as biodegradable, i.e., Poly (L-lactide) (PLA) [91], polyglycolide (PGA) [92], and non biodegradable, e.g. Polyurethane [93].