Pharmacology
Jessica has used Nurofen Gel to ease her aching muscles. Discuss the benefits of this route of administration over an oral capsule in providing a higher bioavailability of the drug. (4 marks)
Discuss the importance of the half-life of a drug. What is the estimated half-life of ibuprofen (the active ingredient in Nurofen gel)? Using this estimate, calculate the amount of time it would take to achieve steady-state concentration and explain the importance of achieving steady state. (3 marks)
Sample Solution
Pharmacology Drug half-life (t1/2) is defined as the amount of time required for the drug concentration to be reduced to exactly half its initial concentration or amount in the blood. The half-life of the drug is useful in determining the dosing frequency. Ibuprofen was originally developed as an anti-rheumatic drug in 1961 and was first introduced by prescription 1969 in Great Britain. As an NSAID, ibuprofen is a non-selective inhibitor of cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2). Ibuprofen is rapidly absorbed, reaching peak serum levels one to two hours after administration, and has a half-life of 1.8 to two hours. It can take up to 24 hours to completely rid your system of ibuprofen.
fact that evil plagues this world in multitude and enormity consolidates the foundation of atheism. There are four versions of this argument. The first version of the argument from evil comprises of three premises.
- The first premise asserts that if God must exist as a supreme being worthy of worship then He must be a being attributed with all power, knowledge and goodness .
- The second premise argues that if God is all-PKG then the existence of evil is impossible.
- The third premise asserts that evil is present in the world.