After completing this weeks assigned readings, Can anyone answer the following questions about disorders of the white cells. Choose 2 questions to answer
What are the most common causes of leukocytosis in the hospital inpatient setting?
Which medications can cause neutropenia and agranulocytosis?
What are the most common causes of eosinophilia?
What key WBC findings indicate an impending medical emergency and warrant immediate action?
What are the indications for a bone marrow biopsy and aspirate?
What is the role of molecular testing in the diagnostic workup of common WBC disorders?
What is the role for granulocyte colony-stimulating factors in nonmalignant hematologic disorders?
WBC disorders
Agranulocytosis is a rare, but serious and life-threatening hematologic disorder in elderly patients. Increasing age and female sex have been considered as risk factors for the development of this condition. Besides, it is well known that older people take on average more drugs than younger people. This condition is most often associated with the intake of antibacterial agents, antiplatelets, antithyroids, antipsychotics, antiepileptics and nonsteroidal anti-inflammatory drugs (NSAIDs). The risk of agranulocytosis is low for most of these but this risk is especially high with clozapine, thionamides (antithyroid drugs), sulfasalazine, cotrimoxazole, ticlopidine, gold salts, phenylbutazone and penicillamine. The causative drug should be immediately stopped.
fe, Alfred was surrounded by science. His father taught him basic principles of engineering and explosives, this went on to be his main interests later in life. Alfred grew up in Stockholm, Sweden, born: 21st October 1833. However, his family moved to Saint Petersburg in 1842 due to his father’s various business failures. Once in the city his father became successful as a manufacturer of tools and explosives. Now wealthy, Alfred’s parents were able to send him to private tutors and he excelled in his studies, specifically chemistry and languages. Fun fact: Alfred Nobel was fluent in English, French, German, Russian and of course Swedish. In 1850, Alfred moved to Paris to continue his studies. He met Ascanio Sobrero, who invented nitroglycerin 3 years earlier. Alfred was intrigued by the instability of Nitroglycerin and went to America to research further. After the Crimean War (1853-1856) Alfred’s father had difficulty switching back to domestic production, so he declared the company bankrupt. In 1859, Immanuel ( his father ) handed the company down to his second son, Ludvig Nobel who went on to greatly improve the business. Nobel devoted himself to the obdurate study of explosives, especially the safe manufacture and use of nitroglycerin. On the 3rd of September 1864, part of a nitroglycerin factory exploded in Heleneborg, Stockholm, killing 5 people including Alfred’s younger brother Emil. However, Alfred continued building factories and developing new technology, unfazed by this. Finally in 1866 Nobel invented dynamite. A more stable compound of Nitroglycerin and Diatomaceous earth, which is a soft rock mostly made of fossilised algae. He moulded it into cylinder shaped sticks and used blasting caps (which he invented a few years earlier) to allow for the safe ignition of such a powerful explosive. He lived the rest of his life being showered in awards from multiple universities and had an award named after him, The Nobel Prize. He was very rich and his money ended up being used to fund these yearly prizes that bear his name. Alfred was a lonely person, he never made a family of his own or got married. He had an interest in literature and often wrote poetry, novels and plays. He once wrote, “Numerous friends are to be found only among dog