olymeric nanoparticles can be defined as colloidal particles ranging between 10 and 1000 nm in size and composed of either natural or artificial polymers [73]. Polymeric nanoparticles composed of the drug dispersed in an amorphous form within a polymer matrix. PNPs are promising vehicles for drug delivery by easy manipulation to prepare carriers with the objective of delivering the drugs to specific targets; such an advantage modifies the drug safety [74].
The compounds of interest are very beneficial for drug delivery applications because of their ability to control drug release and their protection properties [75]. Currently, stimuli-sensitive nanoparticles which affected by the changes in pH, temperature and magnetic fields gained great concern [76-79].

The term “polymeric nanoparticle” encompasses nanospheres and nanocapsules.
Nanospheres are defined as a polymeric matrix in which the drug is homogeneously dispersed (typically as a solid solution in polymer) and nanocapsules are described as a polymeric membrane that surrounds the drug in the matrix core[80] (either as a solid solution or a solution in oil).

Advantages of polymeric nanoparticles include: [81, 82]
(1) improve the stability of any volatile pharmaceutical agents, simply and economically fabricated in large quantities by a huge number of methods, (2) they present a significant improvement over conventional oral and intravenous routes of administration in terms of efficiency and effectiveness, (3) delivers a higher concentration of pharmaceutical agent to the required location, (4) the selection of polymer and the capability of modifying drug release from polymeric nanoparticles have made them typical choice for cancer therapy, delivery of vaccines, contraceptives and delivery of targeted antibiotics and (5) Polymeric nanoparticles can be eas