Bleeding disorder and hypercoagulation

On rare occasions, patients suffering from bleeding disorders such as Hemophilia or von Willebrand Disease (vWD) have suffered from hypercoagulable episodes such as pulmonary emboli or deep vein thromboses.
Using your knowledge of coagulation physiology, explain what influences this occurrence.

Sample Solution

Bleeding disorder and hypercoagulation

The primary, and most evident, complication in patients with inherited bleeding disorders such as hemophilia A, B, and von Willebrand diseases (VWD), is spontaneous and/or posttraumatic bleeding. Although patients with these disorders are relatively protected from thrombosis, both arterial and venous thrombosis do occur on occasion, necessitating management decisions on anticoagulation. Hypercoagulability or thrombophilia is the increased tendency of blood to thrombose. Hypercoagulability describes the pathologic state of exaggerated coagulation or coagulation in the absence of bleeding. A hypercoagulable state and subsequent thromboembolism is a result of overactivity of pro-coagulant factors or a deficiency in anti-coagulants. Arterial thrombosis results from atherosclerotic plague rupture around which a platelet-rich white thrombus forms.

The interview method is a widely used sociological instrument in place marketing and branding studies (E. g., Kavaratzis, 2008, Rainisto, 2003). Interviews can be used to “analyse consumers’ interpretations of their behavior and relationships with brands” (Lunt,2017). My data will consist of interview’s transcripts analysed with the NVIVO. NVIVO is a popular software used for analysing different types of rich data. The Program allows the user to apply a set of various tools to provide detailed analysis of texts and visual data, such as pictures and photos. NVIVO is able to manage data and ideas, query data, visualise it and report from the data (Bazeley and Jackson, 2013).
From the interpretative point of view, the aim of the research is explaining the understanding and perceptions of time by different place’s stakeholders. Interpretive researchers assume that access to reality (given or socially constructed) is only through social constructions such as language, consciousness, shared meanings, and instruments” (Myers, 2008).

Experiments.

Behavioral economics is a field of contemporary economic theory that applies psychological insights into human behaviour to explain economic decision-making. Behavioral economics applies a range of experimental methods to study consumers’ preferences and decision making. Moreover, much attention is paid to time-related aspects of decision making (Thaler, 2015). It is considered, that “people’s preferences appear to change for no reason other than the passing of time” (Angner, 2012). In behavioural economics there is a number of papers devoted to studying public goods (Dragouni et al, 2018). A public good in economics is a good that available to everyone and free. In this terms place brands can be considered a kind of a public good. Public goods are described by non-excludability and non-rivalry, which means everyone has free access to these goods and people can increase their consumption of a good without reducing the availability of the good for others (Samuelson and Noedhaus, 2010). Place brands meet these criteria, because they are not made to be sold, but to fulfil a variety of important social functions (Stubbs and Warnaby, 2015)Moreover, places do not belong to brand managers or corporations, compared to product brands, thus, they can belong to anyone (Dinnie, 2009).

From the behavioural economics point of view, “most decisions have consequences that occur at different points in time” (Angner, 2012). Thus, very often time is considered as a factor. Therefore, applying methods of behavioural economics seems to be appropriate to answer my research question about time and place branding. The

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