Compare quantitative

 

qualitative, and mixed research methods by developing a
table that identifies the key characteristics and applications
of each method, as well as their strengths and weaknesses.

 

Sample Solution

Compare quantitative

There are two main research methodologies: quantitative and qualitative. A third methodology, a combination of the two, is gaining acceptance as a way to improve and substantiate research findings. The quantitative method, which has its origin based in the scientific method, relies on statistical procedures for data analysis. In contrast, qualitative methods rely on the descriptive narrative for data analysis (Berrios & Lucca, 2006). Based in long standing tradition, quantitative studies dominate the research. But, qualitative studies are starting to be recognized as an important source of knowledge. A mixed methods approach has recently emerged which combines quantitative and qualitative methods into a new methodology. It is a procedure for collecting, analyzing, and “mixing” both quantitative and qualitative research and methods in a single study to understand a research problem. Choice of methodology is heavily influenced by the research question.

Pantoprazole is widely used proton pump inhibitor (PPIs) and it is a significant drug in the treatment of acid-related disorders [183] and biliary also effective against Helicobacter biliary infections alone or combined with other drugs, like metronidazole, clarithromycin or amoxicillin [184]. This drug was the first water soluble benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4 – dimethoxy- 2- pyridinyl) methyl] sulfinyl]- 1H- benzimidazole sesquihydrate [185].
A molecule with benzimidazole substitution exhibits potent and long-lasting inhibition of gastric acid secretion by selectively interacting with the gastric proton pump (H+/K+-ATPase) in the parietal cell secretory membrane [183, 186].
The molecular formula is C16H14F2N3NaO4S×1. 5 H2O and molecular weight is 432.4 g/Mol[185]. Because of gradual degradation of pantoprazole sodium during heating, the melting point cannot be accurately determined. It is a white to off-white crystalline powder. The structural formula is: [185]

Pantoprazole has numerous advantages compared to its analogues (e.g., Omeprazole and lansoprazole) such as greater stability in a neutral PH environment, specific site of binding, and longer duration of action [187]. In addition, it shows no potential to either induce or inhibit the CYP 450 [183,184, 188]. It is a more selective inhibitor of acid secretion than other proton pump inhibitors [189].

Pantoprazole is used for treatment of erosive esophagitis, or “heartburn” caused by gatroesop

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