The CEO of the start-up company you are working with from Wk 1 asked you to attend the executive steering committee meeting. The committee is looking to implement a new SCM system. The manufacturing company does not currently have a SCM system and does not believe there is a need for one. The lack of having one causes the company to have occasional operational issues, which results in a loss of revenue.
The executive steering committee has asked you to research the different SCM system software packages available and create a comparison chart of the different packages. They would also like you to provide a summary that will give a recommendation for what SCM system the organization should use.
Research at least four SCM system software packages.
Create a comparison chart for at least four SCM packages you researched that includes the following:
Product
Deployment
Demand Planning
Import/Export Management
Inventory Management
Shipping Management
Supplier Management
Transportation Management
Warehouse Management
Cost
Write a 1-page summary that will help the executives determine what SCM system and strategy to use and that will ensure success. Be sure to include the following in your summary:
A high-level overview of the supply chain
Why each step is important to the organization
How the supply chain will help the company succeed and correct the operational issues.
Demand Planning
Every business needs an effective supply chain management system in place for a good number of reasons. For one, the software helps to make sure that there is a continuous flow of stock into the business without unnecessary interruptions in the deliveries. Supply chain management software applications provide real-time analytical systems that manage the flow of product and information throughout the supply chain network. Top supply chain management software include: E2open, SAP SCM, Logility, Perfect Commerce, and Oracle SCM among others. E2open is an online supply chain management system designed to provide more responsive and demand-driven supply chain.
knowledge about axonal transport impairment in diabetes, focusing on the various components and mechanisms that control such transport both at peripheral (PNS) and central nervous systems (CNS).
Diabetes mellitus and axonal transport
Role of axonal cytoskeleton
Axonal transport impairments and alterations of the cytoskeleton have been associated with numerous types of peripheral neuropathy and also central neurodegenerative diseases (5). Axonal transport takes place along the cellular cytoskeleton which provides structural support to the neuron. The neuronal cytoskeleton is composed by three major components , namely microtubules, intermediate filaments and microfilaments, which can be affected by diabetes.
Microtubules
Microtubules are the main cytoskeleton component responsible for the polarity of the axon. Microtubule minus end defined by the α-tubulin sideis located proximally, nearer to the soma, whereas the the plus end is defined by β-tubulin side, which is located distally, closer to the nerve terminal(6). The polarity of microtubules and consequently of the axon is given by this orientation and therefore directs motors protein to undergo anterograde (toward the plus end) or retrograde (toward the minus end) transport (Figure 1). Conversely, in dendrites, microtubules are found in mixed polarity. Microtubules are essential for axonal transport and any changes in their components may lead to impaired axonal transport under diabetes.
Diabetic neuropathy involves a decrease in axon caliber, axonal transport impairment, and a reduced capacity of nerve regeneration, which are dependent on axonal cytoskeleton integrity for proper nerve function (4). Reduced synthesis of tubulin mRNA and an elevated non-enzymatic glycation of peripheral nerve tubulin was described. Particularly, it was demonstrated that after eight weeks of diabetes T alph