estradiol. It is primarily a potent estrogen antagonist and demonstrates a suppressive or a stimulatory effect on gonadotropin release. It normalizes the bleeding from uterine cavity by regularizing the expression of estrogen receptors on the endometrium and hence used in dysfunctional uterine bleeding.[4] It is cheap, effective and has good patient compliance.
• One minimally invasive procedure for control of menorrhagia is levonorgesterol intrauterine device. The Levonorgestrol ICUD has a reservoir containing 52mg levonorgestrol mixed with polydimethylsiloxane, which controls the rate of hormone release. Menstrual blood loss in women with heavy menstrual bleeding can be reduced by 75-95% due to progestin induced decidualization of the endometrium. Levonorgestrol IUCD is an attractive option for ovulatory women with heavy menstrual bleeding.
• Hysterectomy should be the last resort in management of dysfunctional uterine bleeding, because of the morbidity, mortality associated with the surgical procedure, economic burden, need for rest.
MATERIALS AND METHODS: A comparative study was conducted in 80 patients ( 40 into ormeloxifene group and 40 into levonorgestrel group) of reproductive age group attending the outpatient department or admitted in-patients in department of obstetrics and gynecology at Sri Siddhartha Medical College and Research Centre, Tumkur, during the period of November 2016 to April 2018.
INCLUSION CRITERIA: Women of reproductive age group diagnosed with dysfunctional uterine bleeding.
EXCLUSION CRITERIA: Patient with pelvic pathology-uterine fibroid, PID, adenomyosis, endometriosis, chronic cervicitis and malignancies of uterus / cervix /ovary / vagina / complex endometrial hyperplasia with atypia and platelet disorders, coagulopathy, previous history of thrombosis,Pregnancy and lactation, PCOS, Hypothyroidism, Chronic cervicitis, Jaundice, hepatic dysfunction, Tb, renal impairment, Hypersensitivity to drug were excluded.
An informed written consent from all the women who were included in the study were taken. A detailed history, complete physical examination, routine investigations like hemoglobin, bleeding time, clotting time, platelet, RBS, thyroid function tests, liver function test, transvaginal USG to rule out pelvic pathology and to measure endometrial thickness were done to all patients.
The recruitment of the participants to the study groups were done after ex
