According to the video Ethical Principles in Clinical Research: Ethical Framework: Seven Principles Part 3 by NIH VideoCast, you learned about the seven principles of ethical clinical research.

The seven principles are:

• Valuable scientific question
• Valid scientific methodology
• Fair subject selection
• Favorable risk benefit evaluation
• Independent review
• Informed consent
• Respect for enrolled subjects

The speaker emphasizes that these principles should be applied systematically and sequentially. The framework is designed to be universally applicable across time and location. However, the way these principles are manifested can vary depending on specific situations. For example, the acceptable level of risks may vary depending on the time and location of the research.

Ethics in research are not always clear-cut. There can be gray areas, especially when considering the balance between risks and benefits. For instance, a research study may have the potential to greatly benefit society, but it may also pose some risks to the participants. Researchers need to carefully weigh these risks and benefits and make sure that the potential benefits outweigh the risks.

Here are some ways I can ensure that my research is conducted in an ethical manner:

• I will carefully review the ethical guidelines set forth by the institutional review board (IRB) at my institution.
• I will obtain informed consent from all participants in my research study. This means that I will provide participants with all the information they need about the study, including the risks and benefits of participation.
• I will protect the privacy of all participants in my research study. This means that I will keep all participant data confidential.
• I will be respectful of all participants in my research study. This means that I will treat all participants with dignity and respect.

Some potential challenges I might face in ensuring ethical research include:

• Recruiting participants: It can be difficult to find people who are willing to participate in research studies, especially if the study involves any risks.
• Obtaining informed consent: It can be difficult to ensure that participants truly understand the risks and benefits of participation in a research study.
• Protecting privacy: It can be difficult to keep participant data confidential, especially in the age of electronic health records.

By following these guidelines, I can help to ensure that my research is conducted in an ethical manner.