Exploring tasks that an actual crime scene investigator might accomplish

 

 

In this assignment, you will be exploring tasks that an actual crime scene investigator might accomplish.
There has been a murder in which it is clear that a person riding a mountain bike on the side of a dirt country road was intentionally struck down by a suspect. The suspect then stepped out of his or her vehicle and shot the biker.
A witness riding an ATV heard the shot and came on the scene just in time to see the suspect kick the victim hard a couple of times, presumably to determine if he or she was dead.
You have executed a warrant for the shoes of the driver/shooter and obtained the shoes worn by the suspect for examination.
• Select a pair of shoes from your personal wardrobe, or borrow a pair from someone else. It is important that you select shoes that are at least 6 months old and are worn often (new shoes will not have much evidence on them. Using a household magnifying glass and a strong white light source—either a desk lamp or flashlight—closely examine the pair of shoes you selected.
• Identify 3 or 4 items from the soles of the shoes, and explain in a 3–5-page paper how you conducted your examination, the type of items you found, their possible significance to the crime scene, and how you would recover and package the evidence you found.

You may have access to an ultraviolet light source like the ones used for identifying water marks on money and checks, commonly found at cashiers’ stations. Wear a pair of yellow glasses used as sporting glasses for skiing and shooting. This is just an extra suggestion and is not mandatory for the assignment.
You may also photograph items you have found and attach the photos to the paper if you care to. If you decide to photograph the items, do it on a piece of white bond paper—the photos will turn out better.

Sample Solution

scale. Although histological scale does’nt give more information about prognosis , personalized tretment alternatives and risk of recurrence, molecular scale offers to give a detailed information about diseases processes(14). DNA, RNA, miRNA and protein have been used for molecy-ular analyses to classfy different tumor types into the subtypes. Each of them have an unique prognostic outcome that can not be identified with the traditional morphologic ways(15). Generally molecular scale for classification is used for acute myeloid leukemia, glioblastoma, breast cancer , and renal cell carcinoma , and to differentiate between Burkitt’s lymphoma and diffuse B-cell lymphoma. This classification that offers prognosis and treatment options can help to the patients about management of disease.(16)

Targeted therapy and predictive markers for treatment efficiency

The basic aim of the personalized medicine is applying right therapy to the right population of people by defining disease at the moecular level. So, identifying differences among the individuals support the new treatment methods and pharmaceutical companies to develop new cancer drugs. Patients who have similar clinical outcome and histological tumor type can give different response to the same drug(17). Prediction of who will be a nonresponders reduces the harmfull effect of drug on nonresponders like a potential toxic effect of drug and cost effect. Also when drug companies develop new drug, they focus on the patient population that benefit from drug to increase positive responds(17).

U.S. Food and Drug Administration bringed development about targeted therapy. For example, to treat chronic myeloid leukemia and gastrointestinal stromal tumor(18) ,imatinib mesylate is used and to treat breast cancer(19), trastuzumab (Herceptin) is used. Molecular characteristics of these cancer types that are abnormal protein tyrosine kinase activity in chronic myeloid leukemia and gastrointestinal stromal tumor and HER-2 receptor in breastcancer is used as a predictive biomarker. By using these markers only individuals which have these molecular alteration is selected and it means they are favorable for the treatment. Using this way some cancer types’ survival rate is shifted from 0 to 70%(17).

This application is used in non-small cell lung cancer treatment with using of mutations screeing. In this cancer type mutation occurs in kinase domain of EGFR. Gefitinib (Iressa) and erlotinib are tyrosine kinase inhibitors drug are used to treat and patients give a higher response to the treatment(20). Also if patient that is never smoked Asian females have adenocarcinomas, these drugs efficient on them(21). On the other hand, if the mutatuions occur at downstream effector KRAS, patient is resistant to to erlotinib(22). Also mutations that is at KRAS have a resistance to cetuximab (Erbitux) and panitumumab (Vectibix) drugs in colon cancer patients. If the KRAS is wild type, these these drugs is effective on the patients(23). These responses that are specific and different are based on molecular profile. Some molecular test are done before the using of ce

This question has been answered.

Get Answer
WeCreativez WhatsApp Support
Our customer support team is here to answer your questions. Ask us anything!
👋 Hi, Welcome to Compliant Papers.