Foundational Neuroscience

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As a psychiatric nurse practitioner, it is essential for you to have a strong background in foundational neuroscience. In order to diagnose and treat patients, you must not only understand the pathophysiology of psychiatric disorders but also how medications for these disorders impact the central nervous system. These concepts of foundational neuroscience can be challenging to understand. Therefore, this Discussion is designed to encourage you to think through these concepts, develop a rationale for your thinking, and deepen your understanding by interacting with your colleagues.

Explain the agonist-to-antagonist spectrum of action of psychopharmacologic agents, including how partial and inverse agonist functionality may impact the efficacy of psychopharmacologic treatments.

Compare and contrast the actions of G-protein coupled receptors (GPCRs) and ion gated channels.

Explain how the role of epigenetics may contribute to pharmacologic action.

Explain how this information may impact the way you prescribe medications to patients. Include a specific example of a situation or case with a patient in which the psychiatric mental health nurse practitioner must be aware of the medication’s action. (This is your opportunity to share one of your clinical experiences with us!)

Sample Solution

tially arrested for his involvement in the contractual teachers recruitment scam, based on the info recovered from the Excel sheet maintained by Nit inMahindra.

Later, he was also booked for irregularities in the constable’s recruitment examinations; according to the STF, he recommended names of at least 16 candidates for recruitment as constables. He resigned from BJP in June 2014, after being sent to four days police remand. Sharma claimed innocence, placing the blame on his officer OP Shula, and pointed out that his own daughter had failed PMT twice.

• O. P. Shula

He was posted as Officer on Special Duty with then Technical Education Minister Laxmikant Sharma. Soon after the investigations gained momentum, he went underground and surrendered three months after the investigation team released a look out notice for him. He allegedly tookb84 lakhs Rupees from the candidates for clearing the medical entrance test.

• Sushi Sharma

A mining businessman, Sushi Sharma was once an Officer on Special Duty of the education minister Laxmikant Sharma. He was involved in police constable recruitment examination scam of 2012. After absconding initially, he surrendered to the STF in December 2013.The STF questioned him twice, but did not arrest him. After STF found prosecutable evidence against him, he again went missing. The STF announced a cash reward of rupees 5000 for information on him. He surrendered before the court in 2014, and was arrested by the STF.
During 2010-13, Sharma had provided payoffs to many politicians and bureaucrats, including former Madhya Pradesh BJP chief RabatJohan and his sons, Congress MLA Veer Singh Burial, several ABVP leaders, RSS functionary Suresh Sony, and many civil servants. Laxmikant Sharma was the biggest beneficiary of his kickbacks. He also received large sums of money from educational institutes regularly.

• R. K. Shivhare, Suspended IPS Officer

He is an accused for his alleged involvement in the recruitment of sub-inspector and platoon commander examination of 2012 conducted by Yampa. He is also an accused in gettin

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