Grant proposal Summary

at
Categories
Tags

 

Competency

Identify the role of music, poetry, prose, and visual art in the modern world and workplace.

Scenario

You have been asked to be on the town’s board of Cultural Affairs. When you step into your new role, you quickly realize that the organization is in trouble; the other board members have been on the board for a long time and haven’t done much in recent years. They explain that there is no money in the budget.

You hear about a grant opportunity. Every year, a wealthy resident of your town, Mr. Brown, offers a grant of $10,000 to one local organization. In the past, he has never given this grant to an arts organization because, in the words of another board member, “Mr. Brown does not think the arts are important.”

If you can change Mr. Brown’s mind about the importance of the arts in your community, you might just get the grant and be able to revitalize the town’s cultural arts scene!

Write the grant proposal summary for review by a few board members to be sure you are on the right track for the grant. Instructions

Compose this document in the format of a letter to Mr. Brown. Your letter should include:

three paragraphs using persuasive language.

Sample Solution

and Strebel, 2010; Evans et al., 2010). HIV has Vpu, an accessory protein, that is able to work against this cellular restriction mechanism. Once the viral molecule is budded, it is immature and non-infectious. Maturation of the viral protease enzyme is mediated by itself and is in charge of the cleavage of capsid proteins, and renders the infectious particle (Kohl et al., 1988; Ridky and Leis, 1995).

4.5 HIV VARIABILITY
The reason behind the High viral diversity is the mutation prone nature of the reverse transcriptase enzyme. In HIV, a high rate of spontaneous mutations has been ascribed to the absence of a 3”5′ exonuclease proofreading (Turner et al., 2003). Reverse transcriptase introduces a miss incorporation of a nucleotide once in each 10,000 base sets (Brenner et al., 2002). Along these lines, a patient will have every conceivable mix of HIV nucleotide changes soon after the infection of HIV. Understanding the intra-host and inter-host variability of the virus and genetic differences in patients is vital toward improvement of treatment results (Coffin, 1995).

4.6 RESISTANCE AND FITNESS
The principal inhibitors of viral replication were coordinated against reverse transcriptase and were nucleoside reverse transcriptase inhibitors (NRTIs). Nonetheless, antiretroviral drug treatment has additionally prompted the rise of drug resistance that possibly causes virological and clinical failure. Medication or drug resistance emerges suddenly as a consequence of the error prone reverse transcriptase and give rise to the accumulation of single or multiple mutations in the whole genome of the virus. Resistance mutations commonly happen in the gene targeted by a specific antiretroviral drug and cause the inhibitor’s efficacy to be reduced. Structural changes in the drug targets mediate the acquisition of resistance that decreases the affinity of the drug for the protein.
Michaud et al. said that ‘Genetic barrier for resistance refers to the number of nucleotide changes a virus needs to accumulate to become resistant against a given antiretroviral drug. A high genetic barrier indicates that the virus will need more genetic changes to become resistant, more efficient drug in terms

This question has been answered.

Get Answer