Sample Solution

Polymeric nanoparticles can be defined as colloidal particles ranging between 10 and 1000 nm in size and composed of either natural or artificial polymers [73]. Polymeric nanoparticles composed of the drug dispersed in an amorphous form within a polymer matrix. PNPs are promising vehicles for drug delivery by easy manipulation to prepare carriers with the objective of delivering the drugs to specific targets; such an advantage modifies the drug safety [74].
The compounds of interest are very beneficial for drug delivery applications because of their ability to control drug release and their protection properties [75]. Currently, stimuli-sensitive nanoparticles which affected by the changes in pH, temperature and magnetic fields gained great concern [76-79].

The term “polymeric nanoparticle” encompasses nanospheres and nanocapsules.
Nanospheres are defined as a polymeric matrix in which the drug is homogeneously dispersed (typically as a solid solution in polymer) and nanocapsules are described as a polymeric membrane that surrounds the drug in the matrix core[80] (either as a solid solution or a solution in oil).