How muscle glycogen is used

Case 2:
A 16-year-old female is recently diagnosed with a deficiency of muscle glycogen
phosphorylase. She and her family are concerned and ask the following questions.
Based on what you know about skeletal muscle glycogenolysis and muscle metabolism,
please respond to each question with a thoughtful answer that describes the
metabolism in these various scenarios in language that your patient will understand,
while also being sure to include the role of the relevant metabolic pathways, specific
enzymes, and stimulus for their activity:

1. I’m not sure I understand the issue. Can you explain how muscle glycogen is used
normally during exercise?
2. I really like to take long walks; will Istill be able to do this with my friends?
3. As a result of this deficiency, will I need to get up at night to eat to maintain my blood
glucose levels?
4. Do I need to worry about producing excessive lactate during intense anaerobic
exercise?

 

Sample Solution

During intense, intermittent exercise and throughout prolonged physical activity, muscle glycogen particles are broken down, freeing glucose molecules that muscle cells then oxidize through anaerobic and aerobic processes to produce the adenosine triphosphate (ATP) molecules required for muscle contraction. The rate at which muscle glycogen is degraded depends primarily upon the intensity of physical activity; the greater the exercise intensity, the greater the rate at which muscle glycogen is degraded. As a result, high-intensity activity, such as repeated sprinting, can quickly lower glycogen stores in active muscle cells, even though the total time of activity might be relatively brief (e.g., 10 × 30-s sprints with short recovery intervals).

Section I: INTRODUCTION TO THE STUDY Introduction The country is encountering a basic deficiency of medical care suppliers, a lack that is supposed to increment in the following five years, similarly as the biggest populace in our country’s set of experiences arrives at the age when expanded clinical consideration is vital (Pike, 2002). Staffing of emergency clinics, facilities, and nursing homes is more basic than any time in recent memory as the huge quantities of ‘gen X-ers’ start to understand the requirement for more continuous clinical mediation and long haul care. Interest in turning into a medical caretaker has disappeared lately, likely because of the historical backdrop of the extraordinary and requesting instructive cycle, low compensation, firm and extended periods of time, and fast ‘wear out’ of those rehearsing in the calling (Wharrad, 2003).

A complex oversaw care climate in this country is restricting the dollars accessible to be spent on nursing care. Numerous wellbeing callings, particularly nursing, have the standing of ‘eating their young’ as opposed to offering compelling coaching to develop future medical services suppliers. Because of these variables, the quantity of medical attendants has diminished and businesses regard themselves as understaffed and seeking able work force. Before 2001 the decay had been apparent for a considerable length of time (Sadler, 2003). Nursing schools, public pioneers, medical services pioneers and the overall population is impacted by the absence of Registered Nurses (RNs) accessible.

As the populace ages, the assumption is that a rising number of RNs will be required essentially to keep up with the ongoing degree of medical care. Furthermore, the momentum ecological and political worries of expanding pandemic sickness, event of synthetic and catastrophic events, and expanding dangers of war, requires critical expansions in the medical services labor force (Jefferys, 2001). The public nursing lack and factors that increment the interest for expanding the nursing labor force notwithstanding public, state, and nearby debacles make the potential for a general wellbeing emergency. Nursing programs have endeavored to satisfy need for medical attendants by expanding enlistment and campaigning effectively for expansions in program subsidizing by schools and states for understudies.

Tragically, the issue of nursing understudy weakening hampers the best endeavors of nursing programs and irritates the public lack of Registered Nurses in the United States (Ofori, 2002). In 2003, the National League for Nursing revealed a positive vertical pattern in the nursing labor force supply in any case, the American College of Healthcare Executives (2006) detailed that in 2005, 85% of emergency clinic directors decided medical clinics needed more enlisted medical attendants to fulfill patient consideration needs. The United States Bureau of Labor insights showed by 2014, more than 1.2 million new and substitution nursing positions would be expected to meet the public medical services needs (Ramsburg, 2007).

Various broad endeavors to diminish weakening have been made by nursing programs including reinforcing affirmation methods and executing maintenance programs. Unfortunately, the issues of weakening keep on continuing nursing schools the nation over. Admission to a nursing program is serious and numerous potential understudies are denied confirmation every semester. Steady loss from nursing programs influences not just the particular understudy who is acknowledged to a nursing program and ineffective, yet in addition the understudy denied confirmation that might have been effective. Steady loss rates are expensive to understudies, nursing projects, and medical services the same by diminishing the quantity of likely alumni from schools of nursing and adding to the nursing lack. Many examinations feature the a lot higher than wanted whittling down rates for nursing understudies

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