Memory principles

 

memory principles from the text to make the improvement. You might, for example, strive to improve performance on tests, to recall important dates, to remember people’s names following introductions, or to reduce absentminded actions, such as misplacing keys or a wallet.

After implementing your plan, please write a short paper (about two pages, double-spaced) in which you describe

the aspect of memory you targeted for improvement (and why),
the memory principles or strategies you used (including the rationale behind them), and
any results (positive or negative) from applying these techniques. If you did not have time to apply the techniques, write about what results you expect.
Please make it look simple and don’t use sources other than the PPT and the book if you needed it (Zimbardo, P.G., Johnson, R.L., & McCann, V. (2017).Psychology: Core concepts(8thed.). Boston, MA: Pearson/Allyn and Bacon)

Sample Solution

Memory principles

The brain prioritizes by meaning, value, and relevance. For something to have meaning, you must understand it. Your attitude has much to do with whether you remember something or not. A key factor in remembering is a positive attitude, believing that you will get it right the first time. Your understanding of new material will depend on how much of it can be connected to knowledge you already have. The more you increase your basic knowledge, therefore, the easier it is to build new knowledge on this background. Most of us suffer from memory failure of one kind or another, and most of us would like to improve our memories so that we don’t forget important things. To help make sure information goes from short-term to long-term memory, you can use memory-enhancing strategies such as rehearsal, or the conscious repetition of information to be remembered.

CAR-T cells are engineered to express synthetic receptors that redirect T-cells to surface antigens for tumor elimination. A CAR is a fusion protein composed of 3 domains. These include an extracellular single chain variable fragment that serves as the target binding domain, a transmembrane spacer domain and an intracellular signaling domain with cytoplasmic proteins that provide T-cell activation signals. These domains allow CAR-T cells to recognize cell surface tumor antigens leading to antigen-specific T-cell activation, proliferation, and cytokine production. Many CARs are also designed with elements that enhance T-cell persistence and activity.

After a CAR is designed, it is introduced into T-cells. Initially, through leukapheresis, peripheral blood mononuclear cells from a patient are collected and the blood is separated into different components. Once the immune cells are sequestered, the CAR constructs are transfected into T-cells using plasmid transfection, mRNA or viral vector transduction. More recent approaches to genetically altered T-cells include gene editing tools like CRISPR that create a double stranded break at a particular site within the genome and introduce the CAR gene. Although complex, this technique minimizes the risk of unrestrained genomic integration. The T-cells are then infused back into the patient.

The benefits of CAR-T-cell therapy include the MHC independent antigen recognition CAR-T cells provide. This lessens the impact of mechanisms used by tumor cells for immune escape such as the downregulation of MHC molecules. CAR-T-cells can also be used in patients regardless of their specific human leu

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