Nucleic Acids Chemistry

 

State concisely the goals of the proposed research and summarize the expected outcome(s), including the impact that the
results of the proposed research will have on the research field(s) involved.
• List succinctly the specific objectives of the research proposed (e.g., to test a stated hypothesis, create a novel design, solve a
specific problem, challenge an existing paradigm, address a critical barrier to progress in the field, or develop new technology).
B. Significance (1.0 Pages):
• Explain the importance of the problem or critical barrier to progress that the proposed project addresses.
• Describe the scientific premise for the proposed project, including consideration of the strengths and weaknesses of published
research or preliminary data crucial to the support of your proposal.
• Explain how the proposed project will improve scientific knowledge, technical capability, and/or clinical practice in one or more
broad fields.
• Describe how the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field will
be changed if the proposed aims are achieved.

 

Sample Solution

Nucleic Acids Chemistry

Nucleic acids are naturally occurring chemical compounds that serve as the primary information-carrying molecules in cells. The two main classes of nucleic acids are DNA and RNA. The year 2013 marked the 60th anniversary of the elucidation of the structure of the DNA double helix by Watson and Crick (Watson, J.D.; Crick, F.H.C. Nature 1953, 171, 737-739). Its molecular structure comprises a backbone of repetitive units of sugar phosphate, with each sugar bearing one of the four nucleobases (A/G/C/T) through glycosidic linkages. The double helical superstructure DNA spawned the understanding of the molecular basis of life in terms of how those genetic code could both decode and propagate.

In the 1793-1830’s the United States had two significant various sorts of states. The one sort of state was the free-state which would be known as the North. Those states included Massachusetts, New Hampshire, Vermont, New York and Rhode Island. The accompanying states were known for being more factorial work place, these states were more industrialized than the South. Rather than utilizing human hands and work the Northern states utilized hardware. Having the North supplant human work with machines implied that bondage was not required. Notwithstanding, in the South the interest for cotton emerge between 1790-1860. This request prompted the increment of subjugation, from 700,000 slaves in the last part of the 1790’s to 4.5 million slaves during the 1860s. To separate the North and South expresses, the United States embraced the Mason-Dixon line in 1779 made by Charles Mason and Jeremiah Dixon. Whenever the Northwestern Ordinance of 1787 which arrange the Ohio valley into five new domains, which could be up for statehood. The contention here would be somewhat or not the states ought to be free or slave states. This mandate would ultimately prompt the Cold War between the South and the North. During this period there was pressure between the North and the South, on the grounds that the country all in all believed there should be an equilibrium. This contention would be addressed by the Missouri Compromises of 1820, or so the country thought. Struggle broke out between the states, the two states needed to be the larger part expresses, this lead to brutality which lead to the Civil War.

The expanded interest of cotton in the Great Britain and in the Northern conditions of the U.S, was the explanation of the estates of cotton and tobacco in the U.S South. These states included to Southern states – Virginia, South and North Carolina, Georgia, Alabama, Mississippi, Louisiana, Florida, Tennessee, Arkansas, Missouri and Texas. The south was incredible to deliver those items as a result of the rich soil. The interest of those items prompted work requests too. So they began bringing more slaves and involving them as a work. In 1793 there was 700,000 slaves and it grew up to 4.5 million out of 1860. Cotton creation per y

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