Opioid use is tolerance

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1. An issue that can occur with long-term opioid use is tolerance. Explain drug tolerance; what is the result of drug tolerance?
2. What are the most common side effects and adverse effects of opioids?
3. What is the difference between drug dependence and drug addiction?
4. Why did the federal government file criminal charges against Purdue Pharma in 2007; what was the outcome of the case?
5. Click on the following links and answer the questions related to the October 2020 update on charges against Purdue Pharma: https://www.justice.gov/opa/pr/justice-department-announces-global-resolution-criminal-and-civil-investigations-opioid
A. How much was the settlement that the Federal government reached with Purdue Pharma in October 2020?
B. How much did the Sackler family agree to pay?
C. What charges did the company​‌‍‍‍‌‍‍‌‍‌‌‍‍‍‌‍‌‌‌‍​ agree to plead guilty to? https://www.reuters.com/article/us-purdue-pharma-opioids-plea/oxycontin-maker-purdue-pharma-pleads-guilty-to-criminal-charges-idUSKBN2842SQ
D. To whom did Purdue pharma pay kickbacks?
E. How much money did the company make from the sale of OxyContin?
F. Since 1999, how many people in the United States have died from opioid-related overdoses?
6. Approximately how many people in America died from an opioid overdose in 2021? How does that number compare to deaths from opioid overdose in 2020? How did the COVID Pandemic affect the number of overdose deaths in 2020?
7. In April of 2018, what overdose-reversing drug did the US Surgeon General recommend that all Americans carry? Explain how the drug works (mechanism of action).
8. Discuss at least 3 ways that health care providers can aid in combating the opioid crisis in America​‌‍‍‍‌‍‍‌‍‌‌‍‍‍‌‍‌‌‌‍​.

Sample Solution

Drug tolerance occurs when someone`s body or brain no longer responds to a prescription or recreational drug in the same way it once did. In many cases, tolerance happens when someone has been taking a certain drug for an extended period of time. The receptors or enzymes in their brain and body are less activated by the drug, so it is not as effective. This means that in order to experience the same effects they initially did, they need to increase their dose of the drug. A doctor can prescribe a higher dose of a person`s medication if they have developed a tolerance. With certain classes of drugs, like opioids, tolerance can increase the risk of dependence, addiction, and overdose. When your body develops tolerance, using higher doses increases the risk of overdose.

regards to the osmosis of pieces into lumps. Mill operator recognizes pieces and lumps of data, the differentiation being that a piece is comprised of various pieces of data. It is fascinating to take note of that while there is a limited ability to recall lumps of data, how much pieces in every one of those lumps can change broadly (Miller, 1956). Anyway it’s anything but a straightforward instance of having the memorable option huge pieces right away, somewhat that as each piece turns out to be more natural, it very well may be acclimatized into a lump, which is then recollected itself. Recoding is the interaction by which individual pieces are ‘recoded’ and allocated to lumps. Consequently the ends that can be drawn from Miller’s unique work is that, while there is an acknowledged breaking point to the quantity of pieces of data that can be put away in prompt (present moment) memory, how much data inside every one of those lumps can be very high, without unfavorably influencing the review of similar number

regards to the osmosis of pieces into lumps. Mill operator recognizes pieces and lumps of data, the differentiation being that a piece is comprised of various pieces of data. It is fascinating to take note of that while there is a limited ability to recall lumps of data, how much pieces in every one of those lumps can change broadly (Miller, 1956). Anyway it’s anything but a straightforward instance of having the memorable option huge pieces right away, somewhat that as each piece turns out to be more natural, it very well may be acclimatized into a lump, which is then recollected itself. Recoding is the interaction by which individual pieces are ‘recoded’ and allocated to lumps. Consequently the ends that can be drawn from Miller’s unique work is that, while there is an acknowledged breaking point to the quantity of pieces of data that can be put away in prompt (present moment) memory, how much data inside every one of those lumps can be very high, without unfavorably influencing the review of similar number

regards to the osmosis of pieces into lumps. Mill operator recognizes pieces and lumps of data, the differentiation being that a piece is comprised of various pieces of data. It is fascinating to take note of that while there is a limited ability to recall lumps of data, how much pieces in every one of those lumps can change broadly (Miller, 1956). Anyway it’s anything but a straightforward instance of having the memorable option huge pieces right away, somewhat that as each piece turns out to be more natural, it very well may be acclimatized into a lump, which is then recollected itself. Recoding is the interaction by which individual pieces are ‘recoded’ and allocated to lumps. Consequently the ends that can be drawn from Miller’s unique work is that, while there is an acknowledged breaking point to the quantity of pieces of data that can be put away in prompt (present moment) memory, how much data inside every one of those lumps can be very high, without unfavorably influencing the review of similar number

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