Sample Solution

Paget’s disease is a chronic medical condition that affects the bones, causing them to become enlarged and deformed. It results from an abnormally rapid breakdown of old bone followed by excessive formation of new bone (Kumar & Clark 2005). The pathophysiology of Paget’s disease involves overproduction of certain messengers in the body that disrupt normal bone replacement processes. This leads to areas where the destruction and subsequent rebuilding of bones happens too quickly, resulting in weakened and misshaped bones.

Clinical manifestations associated with Paget’s disease depend on which area is affected but may include joint pain, stiffness or difficulty moving; skeletal deformities such as scoliosis or bowed legs; hearing loss due to involvement of the middle ear bones; headaches and vision problems due to involvement of cranial bones; tinnitus caused by nerve pressure within abnormal skull shape (Kumar & Clark 2005). Diagnosis is typically based on physical examinations combined with imaging studies such as x-rays or CT scans which can detect any abnormalities present in the affected area (Mankin et al., 2009). Treatment usually involves medications such as bisphosphonates that can help slow down or stop further destruction while physical therapy helps maintain mobility within joints that are affected by Paget’s disease (Marston et al., 2008).