Project team at Quality Chemicals

 

 

 

Background:
You are a member of a project team at Quality Chemicals, Inc. Quality Chemicals is a moderately sized chemical company with $200 million in annual sales. Quality has both continuous as well as batch manufacturing capabilities, but their batch manufacturing assets are currently underutilized. The Quality manufacturing facilities were recently inspected by the FDA and found to meet all good manufacturing requirements (GMP) to product bulk pharmaceuticals.
Your team is in the process of evaluating two new product opportunities from Pfizer Pharmaceuticals. One of the products is an active ingredient for an existing Pfizer product which has five years of exclusivity left on its patent before it goes generic. The drug substance is used in the cough and cold market and the annual requirement is about 150 metric tons, although the profit margin is only 5% (fully allocated).
The second product is a key intermediate for a developmental drug to treat deep vein thrombosis. The synthesis of the compound presents significant technical challenges, but the profit margin is projected to be in excess of 35% (fully allocated). The drug is in Phase III of drug development and is projected to launch within 24 months, which means you will need to produce the intermediate within 12 months in order for Pfizer to complete the synthesis and formulate the product for launch. There are two applications for this drug. One is an acute application with is projected to be about 10 metric tons annually. The second is for a chronic application which is about 85 metric tons annually. Pfizer expects to receive approval for the acute application first within 24 months. However, the chronic application will require additional clinical testing and will not be approved for approximately four years.

 

1. (20%) The cough and cold product is a two-step process. In the first reaction, three reagents are added to the reactor simultaneously. One of the reactants is HCl gas, another is malononitrile and the third is para-nitrobenzaldehyde. The market volume requires the use of a 6,000 liter reactor. The reaction mixture is the rapidly heated for six hours at 115°C with tight temperature control. The second step is a hydrogenation in which a nitro group is reduced and must be carried out at -15°C under strongly alkaline (pH 12) and requires a 4,000-liter reactor. In both cases, the reaction products are crystallized, isolated by centrifugation and dried. Please provide the following information:

– Process flow diagram that includes both reactions
– Materials of construction for all equipment
– Factored capital estimate for ALL equipment components to produce the cough and cold product (use installation factor of 3.2)
– Summary of results for your process hazard review (tests required, special chemical precautions, personal protective equipment, etc.)

Sample Solution

Item arrangement is the manner by which brands are put into non-promoting media like PC amusements, books, famous tunes and stage plays for e.g. supported activitys for the advancement of Cadbury’s chocolate put in the UK TV cleanser ‘Crowning liturgy Street’ after the opening titles and after and before the business breaks; this is influencing the youngsters and attracting them to purchase the Cadbury chocolate since little kids can’t separate this is an include. It is a developing wonder in market, which has gotten generally little consideration from business ethicists. In advertising at the large scale level, there are issues of maintainability and misuse of assets through overconsumption by encouraging covetousness and realism. Promoting works at the center point of riches creation; it pulls in a ton of the general analysis coordinated at free enterprise concerning the disintegration of regular assets and the devastation of nature. At smaller scale level, it pulls in a ton of reactions for explicit instances of double dealing or conning, for example, deluding/wrong sustenance marks or differential value publicizing. There is across the board analysis of showcasing works on advancing items that are unsafe to wellbeing, similar to high-fat and high-salt sustenances, cigarettes and liquor. UK has made Ofcom(Office of Communication) to make the laws with respect to item situation in a way depicted above.The code incorporates an area on ‘Business references and different issues’. Inside this segment, three standards are indicated (under Section 10): (1) supporters must keep up full publication command over customized content, (2)editorial and publicizing must be plainly isolated, and (3) item position is restricted (http://www.ofcom.org.uk/television/ifi/codes/bcode/business/). Item arrangement and regular promoting morals Moral assessment of promoting rehearses has commonly utilized three noteworthy strands of good reasoning, utilitarianism, deontology and excellence morals (Robin and Reidenbach 1987). We are examining 2 of them. An utilitarian assessment of showcasing is for the most part to concentrate on its convenience to society, the way that at a miniaturized scale level, it helps common trades among makers and purchasers, while at a full scale level, it empowers the general public to appreciate the advantages of the division of work. The moral worries of purchasers in regards to item position fit into this classification – item arrangement of firearms and cigarettes, for instance, might be viewed as deceptive by a few customers. An utilitarian assessment may well arrive at the resolution that item arrangement is in fact, a moral practice. This is under the thinking that the expanded deals are the indications of consumer loyalty as can be sensibly accepted in any event for instances of express item situation. Then again, there is the hazard that expanded item situation may, undermine the nature of intervened amusement and data,, hence decreasing social, utility notwithstanding when it increments financial utility. Goodness morals may give the best study of item situation since it centers around the aims and the character of the individual starting the activity as opposed to the moral status of the demonstration itself. By assessing the virtual morals in item position ome focuses which can be attracted are promoting, lawfulness must be the principle basis for passing judgment on the moral status of the motive.A showcasing effort improved the situation the buyers who are very much educated and who realize this is a kind of ad contrasts in moral terms from publicizing to kids who can’t recognize TV programs, amusements, melodies and publicizing. On the off chance that numerous customers know about the method of item position, it will have less impact morally. Numerous youthful shoppers undoubtedly think about the nature and degree of item arrangement as it happens in films, TV appears and other amusement items. Yet, the degree to which even an insightful gathering of people knows about an item situation correspondence while they are simply appreciating the sensational stimulation is extremely hard to build up. Numerous shoppers will say that they are not affected by promoting, but rather this case appears to be not any more tenable than the case of thinking about item position as a showcasing procedure, it doesn’t invulnerable one to trickiness. Consequently, there is a requirement for a moral investigation that bargains with item arrangement, which again can apply an utilitarian, a deontological and an uprightness morals point of view; aside from this it likewise needs to consider circumstance explicit components that emerge from the idea of the item, the level of buyer information, the ramifications of, showcase division techniques, the expectation, of the advertiser and, the natural genuineness of, the strategy for influence utilized.

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