Should all State laws be uniform? What are the reasons the States be allowed to adopt different rules? Or are there any? Hasd this changed since the event of the Pandmeic with Covid?
hronic myeloid leukemia (CML) remains as a malignant clonal disorder featured by virtue of hyperproliferation of myeloid cells localized in peripheral blood, spleen as well as bone marrow [1]. The diagnosis by molecular as well as cytogenetics methods relies on detecting Philadelphia chromosome, featuring reciprocal translocation t(9;22). The consequences of such translocation results in the BCR-ABL oncogene which in turn activates tyrosine kinase that produces abnormal protein activation ending up in deregulation of the hematopoietic stem cells that triggers myeloid cell hyper proliferation ending up to CML. On the other hand, each of the cancerous cell line is being characterized by virtue of intracellular or extracellular biomarkers [2].
The utilization of ‘autoimmune antigen’ for the treating Chronic Myeloid Leukemia acts as a probable alternative. Variety of autoantibodies from the serum autoimmune patients’, are available including those specific antibodies for nuclear antigens. Such antibodies are commonly termed as antinuclear antibodies (ANA). These ANA are indeed specific against autoantigen Ro also known as SS-A else anti-Ro antibodies. These serve as diagnostic marker for detecting the condition. Ro antigen contains two major proteins Ro52 (SSA1, TRIM21, else RNF81) along with Ro60 (TROVE2 else SSA2 ) [3]. The expression levels of TROVE2 is being dramatically elevated in concurrence with the pathological stages representing upregulation with most of tumors. Whenever steps are being taken for knocking down such expre
