Teeth Never Sleep by Angel Garcia

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Choose one of the books you read this semester and write a review of the book. Use the information from this
module to help you develop your book review.
You may choose from any of the following titles:
1. flesh to bone by ire’ne lara silva
2. Zoot Suit by Luis Valdez
3. Teeth Never Sleep by Angel Garcia
4. Year of the Dog by Deborah Paredez
5. Children of the Land by Marcelo Hernandez Castillo*
Your book review must:
be between 2-5 pages long
include a thesis statement that tells us the main argument of the book
include moments from the book that help us understand the main argument of the book
includes both a summary of the text and an analysis of the work
tell the reader whether or not your recommend the book and why

 

 

 

 

 

Sample Solution

Teeth Never Sleep by Angel Garcia
Drawing on folklore and fantasy, childhood memory and hallucination, and marked by a tone of piercing divulgence, Teeth Never Sleep nimbly negotiates the split consciousness a culture of dominance requires of men [especially of color], highlighting the fissures in self-hood created by the pressure to seek submission over intimacy while still wanting desperately to be loved, and tracing the contorted route by which emotional pain finds expression in violence. The speaker in one of the poems confesses: the night my girlfriend tells my mother I beat her, I feel betrayed. This was a secret we kept between us. That night, I was no longer my mother’s loving son. I never wanted to be this kind of animal. In a culture of weaponized masculinity, the poems make a doorway of a wound, inviting readers to walk through and sit down inside the raw pain they harbor to meditate on two central, urgent questions: what it means to be a man and how, as a man, to love.

gastric enzymes, to lessen irritation of the gastric mucosa, and to deliver drugs selectively to the site of absorption [94, 95]. Enteric coating materials are polymers, which have acid groups. In the acidic medium of the stomach the acid groups are nonionized, and the coating material is insoluble. Fast dissolution and drug release take place in the upper intestine as a function of pH change in the environment. The polymer acid groups are ionized at higher pH and the material dissolves [95].

Cellulose acetate phthalate (CAP) was the first synthetic polymer described in 1937, which gained soon high popularity as a gastric resistant polymer.
Later polyvinyl acetate phthalate (PVAP) and hydroxypropyl methylcellulose phthalate (HPMCP) were preferred, because of their lower permeability in the gastric fluid and improved stability against hydrolysis. Today the methacrylate copolymers Eudragit® L and S are two of the most widely used polymers for this purpose.

The drug release from the pH-sensitive nanoparticles follows certain mechanisms which include:
1- Drug burst releases when the nanoparticle carriers dissolve at specific pH conditions:
They usually exhibited burst release profiles because of the dissolution characters of the carriers; drug release from conventional nanoparticles was mainly by diffusion. For pH- sensitive nanoparticles, at low pH, the nanoparticles prepared from polycarboxylic acid were solid matrix encapsulating drug, little drug released. As they reach the small intestine, the pH changes from acidic to neutral (6–7.4), carboxylic acid groups deprotonated, the linear polymers dissolved and drugs released rapidly.

2- Drug releases when the polymers swell at specific pH conditions:
Another reason for drug release from nanoparticles was the swelling of the materials [96].
At low pH, the polymers, particularly cross-linked polymers, have a compact structure, which considerably decreased the porosity of the matrix. This caused a slower release of drug as a result of the greater resistance for diffusion of the drug out of the nanogel. However, at higher pH, the nanogel particles were in a swollen state with a higher porosity that favored the release of the drug because of the reduction in diffusion resistance.
3- The drug releases as a result of both polymer dissolution and swelling:
There was obscure boundary between drug dissolution and swelling for the carriers. Some nanoparticle systems might release drug through both the mechanisms. Li et al., 2006 [97] studied the release of insulin from chitosan–Eudragit L100-55 nanoparticles in vitro. The results proposed that at low pH, the nanoparticles were covered by Eudragit L100-55, little water permeated into the particles and when the pH value was elevated to 5.8, Eudragit L100-55 dissolved and water penetrated to the core of the particles. The particle size become larger as chitosan swelling and the higher porosity of chitosan caused rapid insulin release.

Depending on their characters, pH sensitive nanoparticles can be mainly divided into two types. One induces drug release at higher pH because of ionizable functional groups on the pol

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