The formation of flagella in sperm.

 

1. You are studying the formation of flagella in sperm. The following dynamic stability graph
(looking at cytoskeleton length) was generated from the addition of different components to
growth media. At each time point (letter) a drug / protein / molecule was added and the
change in length was seen. For each letter, state what might have been added to the media
and your rationale.
For your answer, just list A-G and state the drug / protein / molecule added and why it affected the length
of the flagella. You cannot use the same drug / protein / molecule twice.
2. What technique would you use to visualize the experiment in question 1. Explain (a) how
the technique works, (b) why you chose that technique, and (c) what you would expect to
see during the experiment.
3. On the home page for chapter 13 was an image of a cell
extending its filopodia and coronaviruses moving along the
filopodia to reach the next cell. Draw a cell with an extending
filopodia. Label the cytoskeleton components, including the
accessory proteins that you would find in the filopodia.
4. Draw 4 normal epithelial cells, the basal lamina, and ECM. Label the cell-cell junctions, cellECM junctions, and components of the ECM. Now, draw a metastasizing melanoma cell
breaking through the basal lamina and crawling away from its original location.
5. Draw 2 cardiac cells – the first sending the signal to contract to the second cell. The second
cell is then contracting. Be sure to include the signaling molecule and what a contraction
looks like at the molecular level.
6. You are studying smooth muscle contraction. You add non-hydrolyzable ATP. This means
ATP cannot be hydrolyzed to ADP and Pi. Diagram what happens during a normal smooth
muscle contraction and explain what would happen when this form of ATP is added. Be
specific!
7. What is this diagram representing? And what is each box (A-C) pointing to?
A. shared cell component
B. Name the
space
C. What could these
represent? Give 3 possibilities.
8. Fill in the chart below. What I want you to determine is what would happen to a healthy
tissue if the following proteins were missing. Pretend we can magically make these proteins
disappear. I have given you a specific tissue type for each protein. (Hint: think about what
the normal function of that protein is for that specific tissue and then answer what would
happen to the cell / tissue if the protein magically disappeared.) Be specific in your
answer. Be sure your answer relates to the specific protein and tissue type.
Be sure to cite your sources if you look up information.
protein that
magically
disappears
tissue / cell type effect on cell / tissue type
MMPs cancer
claudins intestine
connexin cardiac cells
GTP-tubulin cancer
dynein sperm
ankyrin RBC (red blood
cell)
collagen skin
integrins crawling cell

 

Sample Solution

 

 

 

Picasso’s Painting Les Demoiselles d’Avignon

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picasso les demoiselles d avignonWe can just envision the effect that this life-size artwork had on watchers 100 years prior. “Les Demoiselles d’Avignon” displays an audacious dismissal for the made-up rules of craftsmanship. In spite of the fact that the artwork was not indicated freely until 1916, Georges Braque saw the canvas in 1907 in Pablo Picasso’s studio before the paint dried. What’s more, what Braque saw changed the hereditary code of his knowledge until the end of time. I speculate that for some specialists today, “Les Demoiselles d’Avignon” has lost none of its pizzazz. Its conflict of powers and thoughts transmits a force that doesn’t blur.

Craftsmanship history specialists normally talk about the Demoiselles as far as substance: a massage parlor—five whores in a puzzling room that incorporates a table with still-life (natural product), vaporous textures (tablecloth, window ornaments, garments, backdrop), and perhaps a seat; as far as three significant impacts: Primitivism—communicated through plain sexuality, evenness, geometric structure, and references to Egyptian profile-workmanship (the lady at the left) and African ancestral veils (the two right figures); El Greco (extension/vertical twisting); and Cézanne (geometrization and shallow profundity of the pictorial field, just as echoes of Cézanne’s compositions of bathers in the course of action of nudes); regarding illustrative gadgets: the owl-like head swivel of the situated lady on the right (an early, exacting case of “synchronization”) and the profile-like leveling of the noses of the two ladies second and third from the left; or as far as the geometric proper numbers that involve the skeptical tasteful framework (triangles, wedges, precious stones, ovals, trapezoids, and mixes of these shapes), another sign of the long shadow cast over the entire canvas by Cézanne.

In any case, standard conversations once in a while test the more profound spatial capabilities of the composition. Analysts do concur on the rudiments: the 3-D picture space dwells in a domain of uncertainty, connoted partially by forceful dissecting and foregrounding of body parts, (for example, the left hand of the lady on the left, the left leg of the second lady from the left, and the leader of the situated lady on the right). Through these and different gadgets of visual clash, Picasso got back on track and plumbed an inalienably structural part of the work of art’s association: space. Because of Picasso’s quest for better approaches to sort out a stylish field and accommodate 3-D structure with the level picture surface, the Demoiselles viciously overturned the “laws” of straight point of view held consecrated since the Renaissance and tested the shows we partner with how to speak to ordinary space.

At last, as painter/essayist John Golding and others have commonly watched, the transaction of structure and space in the Demoiselles adds to a Cézanne-like round of assertion and forswearing opposite the dream of perspectival space versus the truth of the levelness of the artwork’s canvas. Collapsed surfaces (textures), collapsed structures (bodies and dividers), and collapsed spaces (inside/outside) show up with dumbfounding identicalness—wavering between oppositional values: crack and combination, projection and downturn, volume and plane.

“In Violin” and different arrangements by Picasso, Braque, or Juan Gris, the idea of “Les Demoiselles d’Avignon”— who speaks to what is named as critical space—works as a controlling standard. Furthermore, from painters to stone workers to designers, craftsmen today who tap this ageless rule become structure creators, yet in addition space producers. These specialists get familiar with the key to turning out to be plan creators.

This paper composed by Madison Gray and significant changes have been made. The full duplicate of this exposition is at: https://archive.org/subtleties/PicassoLessons

craftsmanship article, paper about fam

 

 

 

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