The importance of the virome and pathobiome in health and disease
My dissertation is about discovery of novel viruses and the role of multiple infections in disease development.
I would like you to write a specific subsection of the dissertation introduction, entitled “on the importance of the virome and pathobiome in health and
disease”.
It should start with a brief explanation on what is the virome. The explain how in the last years the research on the virome has increased, make a point on
that the advances in metagenomics have helped, but not very extensive as there is already a section into that.
Thereafter, analyze what are the effects of the virome in both stablishing healthy subjects but also into causing disease. Include some examples wherein it
has been investigated/demonstrated that a disbalance virome has been the causation of disease (better if it is in animal health, but human health is also
okay).
Sample Solution
The human body hosts vast microbial communities, termed microbiome. Less well known is the fact that the human body also hosts vast members of different viruses, collectively termed the “virome.” Human virome is the collection of all viruses that are found in or on humans, including both eukaryotic and prokaryotic viruses. The human virome is unique to each individual and includes many viruses, including previously uncharacterized bacteriophages, which may play a defensive role against pathogens (Minot et al., 2013). The development of high-throughput sequencing technologies was revolutionary for viromics research. In recent years, a range of technologies has been developed, which aim to overcome the problems associated with short-read sequencing and fill in these gaps.
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