The use of pharmacological thromboprophylaxis

 

Does the use of pharmacological thromboprophylaxis reduce the risk of deep vein thrombosis in patients with lower limb immobilisation after injury?

 

 

Sample Solution

Patients with injury and lower limb immobilization are at increased risk of thromboembolism. Venous thromboembolic (VTE) disease is a major global cause of morbidity and mortality. An estimated 10 million episodes are diagnosed yearly; more than one‐half of these episodes are provoked by hospital admission/procedures and result in significant loss of disability‐adjusted life years. Temporary lower limb immobilization after injury is a significant contributor to overall VTE burden. This risk may be modifiable. Existing evidence suggests that pharmacological prophylaxis could reduce overall VTE event rates in these patients, but the proportional reduction of symptomatic events remains unclear. Thromboprophylaxis with either fondaparinux or LMWH appears to reduce the odds of both asymptomatic and clinically detected VTE in people with temporary lower limb immobilization following an injury. Treatment effects vary by outcome and are not always conclusive.

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