Sample Solution

according to the raw materials, physicochemical characteristics (size, charge, number of lamellae, permeability), preparation methods, in vivo behavior. In a classification according to the materials used in their preparation, NPDDS can be of lipidic nature as liposomes, micelles, Transfersomes, and solid lipid nanoparticles, or of polymeric nature as nanoparticles, micelles, and niosomes [65-67].

Various materials can be used to prepare nanoparticles such as proteins, polysaccharides and synthetic polymers. The choice of matrix materials is dependent on numerous factors, including : (a) size of nanoparticles required; (b) natural properties of the drug, e.g., aqueous solubility and stability; (c) surface characteristics such as charge and permeability; (d) degree of biodegradability, biocompatibility and toxicity; (e) Drug release profile wanted; and (f) Antigenicity of the final product.

In recent years, polymer–nanoparticle composite materials have attracted the attention of a number of researchers, due to their synergistic and hybrid properties derived from several components. Whether in solution or in bulk, these materials offer unique properties (mechanical, electrical, optical and thermal) [69].
The field of polymer nanoparticles (PNP) is rapidly growing and playing a pivotal role in a broad spectrum of areas ranging from electronics to the Photonics, conducting materials to sensors, medicine to biotechnology, pollution control of environmental technology, and so forth, during the last decades [70, 71] . New and newer polymers have been trying to develop nanoparticles for their application as drug carriers. Craparo et al., 2008 described the preparation and physicochemical and in vitro biological characterization of nanoparticles based on PEGylated, acryloylated polyaspartamide polymers.

Polymeric nanoparticles can be defined as colloidal particles ranging between 10 and 1000 n