Sample Solution

The latest advances in nanotechnologies, especially in nanoparticles, make them very promising in the delivery of therapeutics, drug discovery and diagnostics [13].
The delivery of therapeutic compound to the target site is a major trouble in the treatment of various diseases. A conventional application of drugs is characterized by limited effectiveness, poor biodistribution, and lack of selectivity [14]. The nanoparticles (NPs) as drug delivery systems may offer a number of advantages such as protection of drugs against degradation, targeting the drugs to specific sites of action, organ or tissues, and delivery of biological molecules such as proteins, peptides, and oligonucleotides.

Applications of drug nanoparticles include: both biodegradable nanoparticles for systemic drug delivery and nonbiodegradable nanoparticles for drug dissolution modification have been studied [15-18]. Proposed applications for drug nanoparticles vary from drug targeting and delivery [15, 17, 19-23] to even gene [24-26] and protein [27, 28] therapies. Administration of nanoparticles by, for example, parenteral [16] ocular [29-31] , transdermal [32], and oral routes have been studied. However, the oral route is still the most convenient, preferred, and in a lot of cases, also the